Journal: Movement disorders : official journal of the Movement Disorder Society

Article Title: Paradoxical Modulation of STN Beta-Band Activity with Medication Compared to Deep Brain Stimulation

doi: 10.1002/mds.29634

Figure Lengend Snippet: ( a ) (left panel) Schematic of Abbott infinity DBS segmented lead (image courtesy Abbott). (right panel) Lead and subthalamic nucleus reconstruction based on pre-operative 7T MRI and post-operative CT scans. Lateral, medial, and probe’s eye view of 3-D reconstructions are shown (left to right, respectively). Parcellations of motor (blue), associative (green), and limbic (red) territories estimated based on pre-operative 7T diffusion MRI scans are displayed. Contact segments are indicated by labeled arrows to aid visualization of lead orientation. ( b ) Spectrograms over 60 seconds of spontaneous, resting state LFP activity for vertically aligned rings and segments (from left to right) ‘b’, ‘a’, and ‘c’, in the OFF (left panel) and MEDS (right panel) conditions. (a) Schematic of DBS lead. Lead reconstruction and STN parcellations (blue: motor, green: associative, red: limbic). (b) Spectrograms over 60 seconds of spontaneous, resting state LFP activity for vertically aligned rings and segments in the OFF and MEDS conditions.

Article Snippet: The lead was placed in the sensorimotor (i.e., posterior-lateral) region of STN, which was confirmed by observed proprioceptive responses to passive limb movement during intraoperative microelectrode recording (MER) and corroborated by postoperative reconstruction of the lead (Fig. 1A ). ( a ) (left panel) Schematic of Abbott infinity DBS segmented lead (image courtesy Abbott). (right panel) Lead and subthalamic nucleus reconstruction based on pre-operative 7T MRI and post-operative CT scans.

Techniques: Diffusion-based Assay, Labeling, Activity Assay

Journal: Movement disorders : official journal of the Movement Disorder Society

Article Title: Paradoxical Modulation of STN Beta-Band Activity with Medication Compared to Deep Brain Stimulation

doi: 10.1002/mds.29634

Figure Lengend Snippet: (a) Spectrograms over 60 seconds of spontaneous, resting state LFP activity for the vertically aligned contact pair, 1–2a in the OFF, MEDS, DBS, and MEDS+DBS conditions are shown (left to right, respectively). (b) A spectrogram over 100 seconds of spontaneous, resting state LFP activity for the vertically aligned contact pair, 1–2a, in the MEDS+DBS condition shows oscillatory activity as DBS is turned off. (c) Power spectral density (PSD) plots were generated from spectrograms of continuous local field potential recordings from the subthalamic nucleus of a PD patient in the rest state in four conditions, (OFF, MEDS, DBS, and MEDS+DBS). Median and 25–75% percentiles are shown. The 1/f components of power spectra were removed to allow for normalized comparisons across conditions. (Spectrograms in a are not normalized.) (d) Total power in the beta band (13–35Hz) calculated from spectrograms of continuous local field potential recordings in the OFF, MEDS, DBS, and MEDS+DBS conditions are shown (left to right, respectively). (e) Modified UPDRS-III motor subscores assessed at the time of recordings in the OFF, MEDS, DBS, and MEDS+DBS conditions are shown (left to right, respectively). Scores are divided into bradykinesia, rigidity, and tremor subscores (shown top to bottom respectively). Higher scores indicate higher severity of motor signs. Maximum scores for each subscore are listed in the legend. Of note, in the MEDS+DBS condition, the rigidity subscore was 0. (a) LFP spectrograms for contact pair, 1–2a in four conditions (a) and in the MEDS+ DBS condition as DBS is turned off (b). Normalized PSDs (c), total beta-band power (d), and modified UPDRS-III motor subscores in four conditions (e).

Article Snippet: The lead was placed in the sensorimotor (i.e., posterior-lateral) region of STN, which was confirmed by observed proprioceptive responses to passive limb movement during intraoperative microelectrode recording (MER) and corroborated by postoperative reconstruction of the lead (Fig. 1A ). ( a ) (left panel) Schematic of Abbott infinity DBS segmented lead (image courtesy Abbott). (right panel) Lead and subthalamic nucleus reconstruction based on pre-operative 7T MRI and post-operative CT scans.

Techniques: Activity Assay, Generated, Modification

Journal: medRxiv

Article Title: An algorithmic procedure for measuring deep brain stimulation-induced capsular activation using motor evoked potentials

doi: 10.1101/2025.08.26.25334489

Figure Lengend Snippet: a) Circuit diagram of deep brain stimulation in the subthalamic nucleus and adjacent structures. Blue: implanted deep brain stimulation lead. Green: anatomical outline of the subthalamic nucleus. IC: internal capsule. Red sphere: hypothetical volume of tissue activated by the DBS-generated electric field, partially overlapping with the internal capsule. Bottom red shell: activated muscle tissue. b) Diagram of EMG bipolar electrode placement for commonly recorded muscles in this study. ECR: extensor carpi radialis. FCR: flexor carpi radialis (transparent marker indicating placement underneath the anatomical structure). FDI: first dorsal interosseus. c) Example pulse-averaged EMG recordings displaying a motor evoked potential response in nasalis (top) at 10 ms latency and ECR (bottom) at 18 ms latency.

Article Snippet: DBS electrodes (both quadripolar and directional leads: Medtronic 3389, Medtronic B33005, Boston Scientific Vercise Cartesia Directional Lead 2202, and Abbott Infinity 6172) were implanted using microelectrode guidance and standard clinical procedures.

Techniques: Generated, Muscles, Marker